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Important Announcement

Dr. Manisha Madkaikar

Director & Scientist - G

Phone: (+91-22) 2413 2928, ( +91-22) 2413 8518/19
Department: Paediatric Immunology and Leukocyte Biology

Academic Background

  • MBBS University of Mumbai ( Medicine; 1993)
  • MD University of Mumbai (Residency in Internal Medicine & its branches; 1997)

Professional Experience

  • Member of European Society of Immunodeficiencies (ESID)
  • Founder member of Indian Society for Primary Immune Deficiency (ISPID)
  • Life member of The Cytometry Society (TCS)
  • Life member of Indian Society of Haematology and Blood Transfusion
  • Life member of Mumbai Haematology Society

Research Interests

  • Primary Immunodeficiency Disorders
  • Heamatological Malignancy
  • Marrow failure syndrome
  • Flow Cytometry
  • Molecular Biology

Awards & Achievements

  • Dr. N.C. Kelkar award for standing first in M.D. (General Medicine) examination from Seth G.S. Medical College, Mumbai.
  • SSC Gold medal in Social Science
  • ‘Associateship for specialized training of young scientists in niche areas of biotechnology’ awarded by department of biotechnology under which received training in Molecular Immunology at Institute of Child Health, London under Dr Gaspar. From March - Sept 2007.
  • Awarded 3rd prize for Poster ‘Evaluation of expression of Bruton’s Tyrosine Kinase in Monocytes from X- Linked Agammaglobulinemia by Flow Cytometric Analysis.’ Manisha Madkaikar, Kimberly Gilmour*, Bobby Gaspar* presented at 48th annual conference of Indian society of haematology and transfusion medicine held in Lucknow from 15th to 17th November 2007.
  • Best poster award for poster ‘Overview of immunological profile of chronic lymphoproliferative disorders of patients referred to tertiary health care centre from western India.’ Presented at 49th annual conference of Indian society of haematology and transfusion medicine ISHTM 2008, Sept 19 - 21 2008, Pondicherry.
  • Best paper award for the paper ‘Clinical spectrum of Leukocyte Adhesion Deficiency-I from India and antenatal diagnosis for LAD-I for the first time in India.’ Presented at Mumbai Haematology group annual conference held in 7th Nov 2009 at Tata Memorial Hospital, Mumbai.
  • Best oral paper award for ‘Flowcytometric diagnosis of PNH’ at ISHTM held on 19 - 21st Nov 2010, Kolkata.
  • Best poster award for ‘Application of flowcytometry for the diagnosis of Primary Immunodeficiency disorders’ presented at 3rd Annual Meeting of The Cytometry Society’-India held on 19 - 20th Oct 2010 at NCBS, Bangalore.
  • Best oral paper award for ‘Leukocyte Adhesion Deficiency I: To Delineate Molecular Defects in ITGβ2 gene and Utilize it in Prenatal Diagnosis’ 35th Annual conference of the Mumbai Hematology Group held on 3 - 4th march 2012.
  • Best poster award for poster on ‘Diagnosis of Primary Immunodeficiency Disorders by flowcytometry’ 2nd International Conference on Primary Immunodeficiency Diseases’ held on 2 - 4th Feb 2013.
  • Awarded BGRC Oration by Mumbai Hematology Group during the annual conference held on 23rd - 24th march 2013 and oration delivered: ‘Diagnosis of Primary Immunodeficiency Disorders: Our journey so far.’
  • Dr Manisha Madkaikar was awarded “Dr. Armida Fernandez Oration”3ndAnnual CME of Dr. Athavale Foundation & Pediatric Alumni LTMGH (DAFPAL) held on 5th October 2014, at Mumbai. She delivered an oration on ‘PID: Navigating Through Uncharted Territory’.
  • Received best paper award in clinical category for the year 2015, presented by The Cytometry Society, India. The paper entitled ‘Differential antigen expression and aberrant signaling via PI3 / AKT, MAP / ERK, JAK / STAT and Wnt Beta catening in Lin- / CD38 - / CD34+ cells in AML was published in European Journal of Haemtology in April 2015.


Ongoing Publications

  1. Kerketta L, Rao VB, Madkaiker M, Ghosh K, Mohanty D, Jijina F. Biphenotypic expression in a case of acute leukemia with pericentric inv(6)(p12q24). Cancer Genet Cytogenet. 2005 Jun;159(2) : 187-9.
  2. Manisha M, Ghosh K, Shetty S, Nair S, Khare A, Kulkarni B, Pathare AV, Baindur S, Mohanty D. Spectrum of inherited bleeding disorders from Western India. Haematologia (Budap). 2002;32(1) : 39-47.
  3. Ghosh K, Jijina F, Shetty S, Madkaikar M, Mohanty D. First-time development of FVIII inhibitor in haemophilia patients during the postoperative period. Haemophilia. 2002 Nov;8(6) : 776-80. PMID : 12410646
  4. Ghosh K, Madkaikar M, Jijina F, Gandhi S, Shetty S, Mohanty D. Open heart surgery with mitral valve replacement--ordeal of an undiagnosed haemophilia patient. Clin Lab Haematol. 2003 Apr;25(2) : 131-3. PMID : 12641618
  5. Vundinti BR, Madkaikar M, Kerketta L, Jijina F, Ghosh K, Mohanty D, Jijina F. A novel translocation der(4)t(1;4)(q21;q35) and a marker chromosome in a case of myelodysplastic syndrome. Cancer Genet Cytogenet. 2003 Jul 15;144(2):175-6. PMID : 12850381

Completed Publication

  1. Shetty S, Madkaikar M, Nair S, Pawar A, Baindur S, Pathare A, Ghosh K, Mohanty D. Combined factor V and VIII deficiency in Indian population. Haemophilia. 2000 Sep;6(5) : 504-7. PMID11012693
  2. Ghosh K, Joshi SH, Shetty S, Pawar A, Chipkar S, Pujari V, Madkaikar M, Pathare AV, Jijina F, Mohanty Transfusion transmitted diseases in haemophilics from western India. D. Indian J Med Res. 2000 Aug;112:61-4. PMID : 11037680
  3. Ghosh K, Shetty S, Madkaikar M, Pawar A, Nair S, Khare A, Pathare A, Jijina F, Mohanty D. Venous thromboembolism in young patients from western India: a study. Clin Appl Thromb Hemost. 2001 Apr;7(2) : 158-65.PMID : 11292195
  4. Jijina F, Ghosh K, Madkaikar M, Mohanty D. Ophthalmic surgery in haemophilia. Haemophilia. 2001 Sep;7(5) : 464-7.PMID : 11554933
  5. Ghosh K, Madkaikar M, Iyer Y, Pathare A, Jijina F, Mohanty D. Systemic capillary leak syndrome preceding plasma cell leukaemia. Acta Haematol. 2001;106(3) : 118-21. PMID : 11713377
  6. Ghosh K, Gosavi S, Pathare A, Madkaikar M, Rao VB, Mohanty D. Low cost autologous peripheral blood stem cell transplantation performed in a municipal hospital for a patient with plasma cell leukaemia. Clin Lab Haematol. 2002 Jun;24(3) : 187-90. PMID : 12067286
  7. Madkaikar M, Ghosh K, Jijina F, Gupta M, Rajpurkar M, Mohanty D. Tuberculosis and immune thrombocytopenia. Haematologica. 2002 Aug;87(8) : ELT38. PMID : 12161383
  8. Ghosh K, Iyer Y, Basu A, Madkaikar M, Jijina F, Shankarkumar U, Mohanty D. Virological, serological and haemopoietic colony studies and its correlation with the outcome of severe aplastic anemia. Hematol J. 2003;4(4):292-4. PMID : 12872156
  9. Ghosh K, Vundinti BR, Kerketta L, Madkaikar M, Mohanty D, Jijina F. Severe megakaryocytic dysplasia in a case of myelodysplasia progressing to acute megakaryocytic leukemia presenting with dic(1;16)(q21;p13.3) and t(1;22)(p13;q13). Cancer Genet Cytogenet. 2003 Oct 15;146(2) : 176-8. PMID : 14553955
  10. Madkaikar M, Ghosh K.Treating patients of myelodysplastic syndrome with antithymocytic globulin--should we be more selective? Blood. 2003 Nov 15;102(10) : 3851-2; PMID : 14597610
  11. Madkaikar M, Ghosh K. Immunotherapy in benzene-induced aplastic anemia using a biotherapeutic approach--is it durable? Stem Cells Dev. 2004 Apr;13(2):161-2; author reply 162-3. PMID : 15186729
  12. Kedar PS, Nadkarni AH, Phanasgoankar S, Madkaikar M, Ghosh K, Gorakshakar AC, Colah RB, Mohanty D. Congenital methemoglobinemia caused by Hb-MRatnagiri (beta-63CAT-->TAT, His-->Tyr) in an Indian family. Am J Hematol. 2005 Jun;79(2):168-70. PMID : 15929117
  13. Ghosh K, Nair AP, Jijina F, Madkaikar M, Shetty S, Mohanty D.Intracranial haemorrhage in severe haemophilia: prevalence and outcome in a developing country. Haemophilia. 2005 Sep;11(5):459-62. PMID : 16128888
  14. Babu Rao V, Kerketta L, Madkaikar M, Farah J, Ghosh K. Hybrid cytogenetics of chronic lymphocytic leukemia and follicular cell lymphoma in a case of non-Hodgkin's lymphoma. Acta Haematol. 2006;116(2):150-2. PMID : 16914914
  15. Nair AP, Jijina F, Ghosh K, Madkaikar M, Shrikhande M, Nema M. Osteoporosis in young haemophiliacs from western India. Am J Hematol. 2007 Jun;82(6):453-7. PMID : 17278114
  16. Ghosh K, Madkaikar M, Jijina F, Shetty S. Fractures of long bones in severe hemophilia.Haemophilia. 2007 May;13(3):337-9. PMID : 17498087
  17. Madkaikar M, Ghosh K, Gupta M, Swaminathan S, Mohanty D. Ex vivo expansion of umbilical cord blood stem cells using different combinations of cytokines and stromal cells. Acta Haematol. 2007;118(3):153-9. PMID : 17890847
  18. Madkaikar M, Gupta M, Ghosh K, Swaminathan S, Sonawane L, Mohanty D. Optimising methods of red cell sedimentation from cord blood to maximise nucleated cell recovery prior to cryopreservation. Br J Biomed Sci. 2007;64(4):157-9. PMID : 18236736
  19. Ghosh K, Madkaikar M, Jijina F. Spontaneous resolution of severe aplastic anemia following thymic hemorrhage. Acta Haematol. 2008;119(2):69-72. PMID : 18285694
  20. Meera V, Jijina F, Shrikande M, Madkaikar M, Ghosh K. Twin pregnancy in a patient of chronic myeloid leukemia on imatinib therapy. Leuk Res. 2008 Oct;32(10):1620-2. PMID : 18420270
  21. Vundinti BR, Kerketta L, Madkaikar M, Jijina F, Ghosh K. Three way translocation in a new variant of t(8;21) acute myeloid leukemia involving Xp22. Indian J Cancer. 2008 Jan-Mar;45(1):30-2.
  22. Gujral S, Subramanian PG, Patkar N, Badrinath Y, Kumar A, Tembhare P, Vazifdar A, Khodaiji S,Madkaikar M, Ghosh K, Yargop M, Dasgupta A. Report of proceedings of the national meeting on "Guidelines for Immunophenotyping of Hematolymphoid Neoplasms by Flow Cytometry". Indian J Pathol Microbiol. 2008 Apr-Jun;51(2):161-6. PMID : 18603672
  23. Pereira WC, Khushnooma I, Madkaikar M, Ghosh K. Reproducible methodology for the isolation of mesenchymal stem cells from human umbilical cord and its potential for cardiomyocyte generation. J Tissue Eng Regen Med. 2008 Oct;2(7):394-9. PMID : 18615777
  24. Madkaikar M, Gupta M, Jijina F, Ghosh K. Paroxysmal nocturnal haemoglobinuria: diagnostic tests, advantages, & limitations. Eur J Haematol. 2009 Dec 1;83(6):503-11. PMID : 19686268 (Impact Factor: 2.548)
  25. Swaminathan S, Madkaikar M, Ghosh K, Vundinti BR, Kerketta L, Gupta M. Novel immunophenotypic and morphologic presentation in acute myeloid leukemia (AML) with JAK2 V617F mutation. Eur J Haematol. 2010 Feb 1;84(2):180-2. (Impact Factor: 2.548)
  26. Shmukler BE, Kedar PS, Warang P, Desai M, Madkaikar M, Ghosh K, Colah RB, Alper SL. Hemolytic anemia and distal renal tubular acidosis in two Indian patients homozygous for SLC4A1/AE1 mutation A858D. Am J Hematol. 2010 Oct;85(10):824-8. PMID : 20799361. (Impact Factor: 4.138)
  27. Madkaikar MR, Kulkarni S, Utage P, Fairbanks L, Ghosh K, Marinaki A, Desai M. Purine nucleoside phosphorylase deficiency with a novel PNP gene mutation: a first case report from India. BMJ Case Rep. 2011 Dec 8;2011. pii: bcr0920114804. doi: 10.1136/bcr.09.2011.4804. PMID:22669887. (Impact Factor: NA)
  28. Madkaikar M, Mhatre S, Gupta M, Ghosh K. Advances in autoimmune lymphoproliferative syndromes. Eur J Haematol. 2011 Jul;87(1):1-9. PMID:21447005. (Impact Factor: 2.548)
  29. Madkaikar M, Currimbhoy Z, Gupta M, Desai M, Rao M. Clinical profile of leukocyte adhesion deficiency type I. Indian Pediatr. 2012 Jan;49(1):43-5. PMID : 21447005(Impact Factor: 1.036)>
  30. Vaidya S, Madkaikar M, Ghosh K, Vundinti BR. Deletion of ABL/BCR on der(9) associated with severe basophilia. Indian J Hum Genet. 2011 May;17(2):100-3.PMID : 21719937(Impact Factor:NA)
  31. Kawankar N, Korgaonkar S, Kerketta L, Madkaikar M, Jijina F, Ghosh K, Vundinti BR. DNA copy number changes and immunophenotype pattern in karyotypically normal acute myeloid leukemia patients from an Indian population. Genet Test Mol Biomarkers. 2012 Apr;16(4):265-70. PMID : 22090723. (Impact Factor: 1.444)
  32. Van de Vijver E, Maddalena A, Sanal Ö, Holland SM, Uzel G, Madkaikar M, de Boer M, van Leeuwen K, Köker MY, Parvaneh N, Fischer A, Law SK, Klein N, Tezcan FI, Unal E, Patiroglu T, Belohradsky BH, Schwartz K, Somech R, Kuijpers TW, Roos D. Hematologically important mutations: leukocyte adhesion deficiency (first update). Blood Cells Mol Dis. 2012 Jan 15;48(1):53-61. PMID : 22134107 (Impact Factor:2.316)
  33. Gupta S, Madkaikar M, Singh S, Sehgal S. Primary immunodeficiencies in India: a perspective. Ann N Y Acad Sci. 2012 Feb;1250:73-9. PMID : 22224794 (Impact Factor:4.364)
  34. Madkaikar MR, Gupta M, Rao M, Ghosh K. Prenatal diagnosis of LAD-I on cord blood by flowcytometry. Indian J Pediatr. 2012 Dec;79(12):1605-9. PMID : 22477041(Impact Factor: 1.036)
  35. Ghosh K, Swaminathan S, Madkaikar M, Gupta M, Kerketta L, Vundinti B. FLT3 and NPM1 mutations in a cohort of AML patients and detection of a novel mutation in tyrosine kinase domain of FLT3 gene from Western India. Ann Hematol. 2012 Nov;91(11):1703-12. PMID : 22733614(Impact Factor 2.866)
  36. Magerus-Chatinet A, Stolzenberg MC, Lanzarotti N, Neven B, Daussy C, Picard C, Neveux N, Desai M, Rao M, Ghosh K, Madkaikar M, Fischer A, Rieux-Laucat F. Autoimmune lymphoproliferative syndrome caused by a homozygous null FAS ligand (FASLG) mutation. J Allergy Clin Immunol. 2013 Feb;131(2):486-90. doi: 10.1016/j.jaci.2012.06.011. PMID : 22857792 (Impact Factor 10.108))
  37. Madkaikar M, Mishra A, Desai M, Gupta M, Mhatre S, Ghosh K. Comprehensive report of primary immunodeficiency disorders from a tertiary care center in India. J Clin Immunol. 2013 Apr;33(3):507-12. doi: 10.1007/s10875-012-9829-2. PMID : 23108471 (Impact Factor: 3.382)
  38. Gupta M, Madkaikar M, Rao VB, Mishra A, Govindaraj P, Thangaraj K, Ghosh K. Mitochondrial DNA variations in myelodysplastic syndrome. Ann Hematol. 2013 Jul;92(7):871-6. doi: 10.1007/s00277-013-1706-4. PMID : 23475051(Impact Factor: 1.036)
  39. Merchant RH, Parekh D, Ahmad N, Madkaikar M, Ahmed J. X linked agammaglobulinemia: a single centre experience from India. Indian J Pediatr. 2014 Jan;81(1):92-4. doi: 10.1007/s12098-013-1113-9. PMID : 23873299 (0.715)
  40. Madkaikar M, Mishra A, Ghosh K. Diagnostic approach to primary immunodeficiency disorders. Indian Pediatr. 2013 Jun 8;50(6):579-86. PMID: 23942400 (Impact Factor: 1.036) PMID : 23942400
  41. Ghosh K, Madkaikar M, Gupta M, Jijina F. Evaluation of danazol, cyclosporine, and prednisolone as single agent or in combination for paroxysmal nocturnal hemoglobinuria. Turk J Haematol. 2013 Dec;30(4):366-70. doi: 10.4274/Tjh.2012.0199.PMID : 24385826 (Impact Factor: 0.494)
  42. Garg S, Madkaikar M, Ghosh K. Investigating cell surface markers on normal hematopoietic stem cells in three different niche conditions. Int J Stem Cells. 2013 Nov;6(2):129-33. PMID : 24386557
  43. Mhatre S, Madkaikar M, Jijina F, Ghosh K. Unusual Clinical Presentations of Familial Hemophagocytic Lymphohistiocytosis Type-2. J Pediatr Hematol Oncol. 2014 Nov;36(8):e524-7. PMID : 24390453
  44. Mishra A, Gupta M, Dalvi A, Ghosh K, Madkaikar M. Rapid Flow cytometric prenatal diagnosis of primary immunodeficiency (PID) disorders. J Clin Immunol. 2014 Apr;34(3):316-22.PMID : 24535004
  45. Madkaikar M, Gupta M, Chavan S, Italia K, Desai M, Merchant R, Radhakrishnan N, Ghosh K. X-linked hyper IgM syndrome: Clinical, immunological and molecular features in patients from India. Blood Cells Mol Dis. 2014 Sep;53(3):99-104.PMID : 24929972
  46. Mhatre S, Madkaikar M, Ghosh K, Desai M, Pujari V, Gupta M. Rapid flow cytometry based cytotoxicity assay for evaluation of NK cell function. Indian J Exp Biol. 2014 Oct;52(10):983-8. PMID : 25345247
  47. Swaminathan S, Garg S, Madkaikar M, Gupta M, Jijina F, Ghosh K. FLT3 and NPM-1 mutations in a cohort of acute promyelocytic leukemia patients from India. Indian J Hum Genet. 2014 Apr;20(2):160-5. PMID : 25400345
  48. Mishra A, Italia K, Gupta M, Desai M, Madkaikar M. Hyperimmunoglobulin syndrome due to CD40 deficiency: possibly the first case from India. J Postgrad Med. 2015 Jan-Mar;61(1):46-8. PMID : 25511220
  49. Mhatre S, Madkaikar M, Desai M, Ghosh K. Spectrum of perforin gene mutations in familial hemophagocytic lymphohistiocytosis (FHL) patients in India. Blood Cells Mol Dis. 2015 Mar;54(3):250-7. PMID : 25577959
  50. Madkaikar M, Italia K, Gupta M, et al. Molecular characterization of leukocyte adhesion deficiency-I in Indian patients: Identification of 9 novel mutations. Blood Cells Mol Dis. 2015 Mar;54(3):217-23.PMID : 25703682
  51. Madkaikar M, Italia K, Gupta M, Desai M, Aggarwal A, Singh S, Suri D, Mishra A, Chavan S, Ghosh K, Sarangal R, Dogra S. Leukocyte Adhesion Deficiency-I with a Novel Intronic Mutation Presenting with Pyoderma Gangrenosum- Like Lesions. J Clin Immunol.2015 May;35(4):431-4. PMID : 25876705
  52. Garg S, Shanmukhaiah C, Marathe S, Mishra P, Babu Rao V, Ghosh K, Madkaikar M. Differential antigen expression and aberrant signaling via PI3/AKT, MAP/ERK, JAK/STAT, and Wnt/β catenin pathways in Lin-/CD38-/CD34+ cells in acute myeloid leukemia. Eur J Haematol. 2015 May 23.PMID : 26010294
  53. Adams SP, Wilson M, Harb E, Fairbanks L, Xu-Bayford J, Brown L, Kearney L, Madkaikar M, Bobby Gaspar H. Spectrum of mutations in a cohort of UK patients with ADA deficient SCID: Segregation of genotypes with specific ethnicities. Clin Immunol. 2015 Dec;161(2):174-9. PMID : 26255240
  54. Garg S, Shanmukhaiah C, Ghosh K, Madkaikar M. Cell signaling in putative leukemic stem cells and blast population in acute myeloid leukemia. Leuk Lymphoma. 2015 Dec 24:1-4. PMID : 26700494. Impact factor: 2.891
  55. Fleisher TA, Madkaikar M, Rosenzweig SD. Application of Flow Cytometry in the Evaluation of Primary Immunodeficiencies. Indian J Pediatr. 2016 Feb 11. PMID : 26865168. Impact factor: 0.87
  56. Madkaikar M, Shabrish S, Desai M. Current Updates on Classification, Diagnosis and Treatment of Hemophagocytic Lymphohistiocytosis (HLH). Indian J Pediatr. 2016 Feb 13. PMID : 26872683. Impact factor: 0.87
  57. Garg S, Ghosh K, Madkaikar M. Antigen expression on a putative leukemic stem cell population and AML blast. Int J Hematol. 2016 Feb 24. PMID : 26910244 Impact factor: 1.17
  58. Madkaikar M, Aluri J, Gupta S. Guidelines for Screening, Early Diagnosis and Management of Severe Combined Immunodeficiency (SCID) in India. Indian J Pediatr. 2016 Feb 27. PMID : 26920398. Impact factor: 0.87
  59. Kulkarni M, Desai M, Gupta M, Dalvi A, Taur P, Terrance A, Bhat S, Manglani M, Raj R, Shah I,Madkaikar M Clinical, Immunological, and Molecular Findings of Patients with p47phox Defect Chronic Granulomatous Disease (CGD) in Indian Families. J Clin Immunol. 2016 Oct 3.
  60. Shabrish S, Gupta M, Madkaikar M. A Modified NK Cell Degranulation Assay Applicable for Routine Evaluation of NK Cell Function. J Immunol Res. 2016;2016:3769590. doi: 10.1155/2016/3769590. Epub 2016 Jun 20.
  61. Madkaikar M, Gupta M, Dixit A, Patil V. Predominant Neurological Manifestations Seen in a Patient With a Biallelic Perforin1 Mutation (PRF1; p.R225W). J Pediatr Hematol Oncol. 2016 Jun 6
  62. Gupta M, Aluri J, Terrance A, Madkaikar M. Adenosine Deaminase Deficiency with a Novel Gene Mutation. Indian J Pediatr. 2016 Aug;83(8):875-6. doi: 10.1007/s12098-016-2098-y. Epub 2016 Apr 18. No abstract available.
  63. Bacchelli C, Moretti FA, Carmo M, Adams S, Stanescu HC, Pearce K, Madkaikar M, Gilmour KC, Nicholas AK, Woods CG, Kleta R, Beales PL, Qasim W, Gaspar HB. Mutations in linker for activation of T cells (LAT) lead to a novel form of severe combined immunodeficiency.J Allergy Clin Immunol. 2016 Jul 15. pii: S0091-6749(16)30608-X. doi: 10.1016/j.jaci.2016.05.036.
  64. Aluri J, Italia K, Gupta M, Dalvi A, Bavdekar A, Madkaikar M. Low T cell receptor excision circles (TRECs) in a case of ZAP 70 deficient severe combined immunodeficiency (SCID) with a novel mutation from India. Blood Cells Mol Dis. 2016 Nov 5.
  65. Pranatharthiharan S, Patel MD, Malshe VC, Pujari V, Gorakshakar A, Madkaikar M, Ghosh K, Devarajan PV. Asialoglycoprotein receptor targeted delivery of doxorubicin nanoparticles for hepatocellular carcinoma. Drug Deliv. 2017 Nov;24(1):20-29
  66. Screening for DEL phenotype in RhD negative Indians.Kulkarni S, Parchure DS, Gopalkrishnan V, Madkaikar M. J Clin Lab Anal. 2017 Jun 23. doi: 10.1002/jcla.22288.
  67. Kulkarni SS, Vasantha K, Gogri H, Parchure D, Madkaikar M, Férec C, Fichou Y.First report of Rhnull individuals in the Indian population and characterization of the underlying molecular mechanisms.Transfusion. 2017 May 3. doi: 10.1111/trf.14150.
  68. Kerketta LS, Ghosh K, Nadkarni A, Madkaikar M, Vundinti BR. Centrosome Aberration Frequency and Disease Association in B-Acute Lymphoblastic Leukemia. In Vivo. 2017 Mar-Apr;31(2):215-220.
  69. Kedar P, Parmar V, Devendra R, Gupta V, Warang P, Madkaikar M. Congenital dyserythropoietic anemia type II mimicking hereditary spherocytosis in Indian patient with SEC23B-Y462C mutations. Ann Hematol. 2017 Sep 7. PMID:28879554
  70. Mohanty MC, Madkaikar MR, Desai M, Taur P, Nalavade UP, Sharma DK, Gupta M, Dalvi A, Shabrish S, Kulkarni M, Aluri J, Deshpande JM.Poliovirus Excretion in Children with Primary Immunodeficiency Disorders, India. Emerg Infect Dis. 2017 Oct;23(10):1664-1670. doi: 10.3201/eid2310.170724. PMID: 28930011
  71. Kulkarni M, Gupta M, Madkaikar M. Phenotypic Prenatal Diagnosis of Chronic Granulomatous Disease: A Useful Tool in The Absence Of Molecular Diagnosis. Scand J Immunol. 2017 Dec;86(6):486-490. PMID:29063637
  72. Aluri J, Gupta M, Dalvi A, Mhatre S, Kulkarni M, Hule G, Desai M, Shah N, Taur P, Vedam R, Madkaikar M. Clinical, Immunological, and Molecular Findings in Five Patients with Major Histocompatibility Complex Class II Deficiency from India. Frontiers in Immunology. Front Immunol. 2018 Feb 16;9:188. doi: 10.3389/fimmu.2018.00188. eCollection 2018.PMID: 29527204
  73. Kedar PS, Gupta V, Warang P, Chiddarwar A, Madkaikar M. Novel mutation (R192C) in CYB5R3 gene causing NADH-cytochrome b5 reductase deficiency in eight Indian patients associated with autosomal recessive congenital methemoglobinemia type-I.Hematology. 2018 Feb 27:1-7. doi: 10.1080/10245332.2018.1444920. [Epub ahead of print] PMID: 29482478
  74. Fichou Y, Parchure D, Gogri H, Gopalkrishnan V, Le Maréchal C, Chen JM, Férec C, Madkaikar M, Ghosh K, Kulkarni S. Molecular basis of weak D expression in the Indian population and report of a novel, predominant variant RHD allele. Transfusion. 2018 Feb 25. doi: 10.1111/trf.14552. [Epub ahead of print] PMID: 29479713
  75. Molecular genotyping of Indian blood group system antigens in Indian blood donors. Gogri H, Pitale P, Madkaikar M, Kulkarni S. Transfus Apher Sci. 2018 Apr 11. PMID: 29691150


Projects Ongoing:

  1. Establishing center of excellence for Diagnosis and Management of Primary Immunodeficiency disorders (PID) (Funded By ICMR, 2014 - 2022).
  2. Clinical, Immunological and Molecular Characterization of Common T-B + and T-B - Severe Combined Immunodeficiency (SCID) disorder in Indian Population (Funded By ICMR, 2014 - 2018).
  3. Study the role of T cell receptor excision circles (TRECs) in diagnosis of various combined immunodeficiency disorders (CID) (Funded By ICMR, 2017 - 2020).
  4. Role of NK cells in immunopathogenesis of Dengue virus infection (Funded By SERB-DST, 2016 - 2018).
  5. Understanding the role of Neutrophil Extracellular Trap (NETs) formation in pathophysiology of Chronic Granulomatous Disease (CGD) patients (Funded By DBT, 2017 - 2022).
  6. Harnessing induced pluripotent stem cells (iPSCs) technology for understanding the pathophysiology and management of human Primary Immunodeficiency Disorders (Funded By ICMR, 2017 - 2020).
  7. Centre of excellence for Research, Diagnosis and Management of Primary Immunodeficiency disorders (PID) (Funded By ICMR, 2014 - 2022)
  8. Study the role of T cell receptor excision circles (TRECs) in diagnosis of various combined immunodeficiency disorders (CID) (Funded by ICMR, 2015 - 2018)
  9. Multicentric Collaborative study of the National registry for rare disorders in India
  10. I HLH: Establishment of a nationwide prospective web based registry for patients diagnosed with HLH.

Projects Completed:

  1. Understanding of molecular pathology of Chronic Granulomatous disease (CGD) (Funded By ICMR, 2014 - 2017)
  2. Study of pattern of PID in Western India with a view to establish diagnostic algorithm suitable for the population.
  3. Development of a rapid granule release assay for evaluation of genetic HLH.
  4. Understanding molecular pathology of HLH in India.
  5. Immuno and molecular characterization of patients with Hyper IgM Syndrome.
  6. Study of biology of leukaemic stem cells.
  7. Age related blood lymphocyte subset in healthy Indian children - a Multicentric study.

Research Staff

Pediatric Immunology & Leukocyte Biology

Sr. No. Name Designation
1 Dr. Umair Bargir Scientist B
2 Dr. Priyanka Kambli Scientist B
3 Dr. Gouri Hule PDF
4 Ms. Madhurima Sarkar SRF Ph.D Student
5 Dr. Madhura Kelkar SRF Ph.D Student
6 Ms. Manasi Kulkarni SRF Ph.D Student
7 Ms. Janhavi Aluri SRF Ph.D Student
8 Ms. Maya Gupta Ph.D Student
9 Ms.Priyanka Setia Ph.D Student
10 Ms. Sneha Sawant SRF
11 Dr. Snehal Shabrish Research Associate