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Department of Paediatric Immunology and Leukocyte Biology


Name - Dr. Manisha Madkaikar

Degree - MD

Designation - Scientist F, Director In-charge

Email - madkaikarmanisha@yahoo.co.in

Degree University Subject Year
MD Mumbai University General medicine 1997
  • Dr. N.C. Kelkar award for standing first in M.D. (General Medicine) examination from Seth G.S. Medical College, Mumbai.
  • 'Associateship for specialized training of young scientists in niche areas of biotechnology' awarded by department of biotechnology under which received training in Molecular Immunology at Institute of Child Health, London under Dr Gaspar. From March-Sept 2007.
  • Awarded BGRC Oration by Mumbai Hematology Group during the annual conference held on 23rd -24th march 2013 and oration delivered: 'Diagnosis of Primary Immunodeficiency Disorders: Our journey so far.'
  • Dr Manisha Madkaikar was awarded "Dr. Armida Fernandez Oration"3ndAnnual CME of Dr. Athavale Foundation & Pediatric Alumni LTMGH (DAFPAL) held on 5th October 2014, at Mumbai. She delivered an oration on 'PID: Navigating Through Uncharted Territory'.
Research Teacher University Subject
PhD Mumbai University Applied Biology
M.Sc Mumbai University Applied Biology
  • Madkaikar M, Mhatre S, Gupta M, Ghosh K. Advances in autoimmune lymphoproliferative syndromes. Eur J Haematol. 2011 Jul;87(1):1-9.
  • van de Vijver E, Maddalena A, Sanal Ö, Holland SM, Uzel G, Madkaikar M, de Boer M, van Leeuwen K, Köker MY, Parvaneh N, Fischer A, Law SK, Klein N, Tezcan FI, Unal E, Patiroglu T, Belohradsky BH, Schwartz K, Somech R, Kuijpers TW, Roos D. Hematologically important mutations: leukocyte adhesion deficiency (first update). Blood Cells Mol Dis. 2012 Jan 15;48(1):53-61. PMID: 22134107 (Impact Factor:2.316)
  • Gupta S, Madkaikar M, Singh S, Sehgal S. Primary immunodeficiencies in India: a perspective. Ann N Y Acad Sci. 2012 Feb;1250:73-9. PMID: 22224794 (Impact Factor:4.364)
  • Ghosh K, Swaminathan S, Madkaikar M, Gupta M, Kerketta L, Vundinti B. FLT3 and NPM1 mutations in a cohort of AML patients and detection of a novel mutation in tyrosine kinase domain of FLT3 gene from Western India. Ann Hematol. 2012 Nov;91(11):1703-12. PMID: 22733614(Impact Factor 2.866)
  • Magerus-Chatinet A, Stolzenberg MC, Lanzarotti N, Neven B, Daussy C, Picard C, Neveux N, Desai M, Rao M, Ghosh K, Madkaikar M, Fischer A, Rieux-Laucat F. Autoimmune lymphoproliferative syndrome caused by a homozygous null FAS ligand (FASLG) mutation. J Allergy Clin Immunol. 2013 Feb;131(2):486-90. doi: 10.1016/j.jaci.2012.06.011. PMID: 22857792 (Impact Factor 10.108))
  • Madkaikar M, Mishra A, Desai M, Gupta M, Mhatre S, Ghosh K. Comprehensive report of primary immunodeficiency disorders from a tertiary care center in India. J Clin Immunol. 2013 Apr;33(3):507-12. doi: 10.1007/s10875-012-9829-2. PMID: 23108471 (Impact Factor: 3.382)
  • Gupta M, Madkaikar M, Rao VB, Mishra A, Govindaraj P, Thangaraj K, Ghosh K. Mitochondrial DNA variations in myelodysplastic syndrome. Ann Hematol. 2013 Jul;92(7):871-6. doi: 10.1007/s00277-013-1706-4. PMID:23475051(Impact Factor: 1.036)
  • Madkaikar M, Mishra A, Ghosh K. Diagnostic approach to primary immunodeficiency disorders. Indian Pediatr. 2013 Jun 8;50(6):579-86. PMID: 23942400 (Impact Factor: 1.036)
  • Garg S, Madkaikar M, Ghosh K. Investigating cell surface markers on normal hematopoietic stem cells in three different niche conditions. Int J Stem Cells. 2013 Nov;6(2):129-33. PMID: 24386557
  • Mhatre S, Madkaikar M, Ghosh K, Gupta S. Hemophagocytic lymphohistiocytosis: An update. Current Immunology Reviews, 2013, 9, 231-240.
  • Mhatre S, Madkaikar M, Jijina F, Ghosh K. Unusual Clinical Presentations of Familial Hemophagocytic Lymphohistiocytosis Type-2. J Pediatr Hematol Oncol. 2014 Nov;36(8):e524-7.
  • Mishra A, Gupta M, Dalvi A, Ghosh K, Madkaikar M. Rapid Flow cytometric prenatal diagnosis of primary immunodeficiency (PID) disorders. J Clin Immunol. 2014 Apr;34(3):316-22.
  • Madkaikar M, Gupta M, Chavan S, Italia K, Desai M, Merchant R, Radhakrishnan N, Ghosh K. X-linked hyper IgM syndrome: Clinical, immunological and molecular features in patients from India. Blood Cells Mol Dis. 2014 Sep;53(3):99-104.
  • Mhatre S, Madkaikar M, Ghosh K, Desai M, Pujari V, Gupta M. Rapid flow cytometry based cytotoxicity assay for evaluation of NK cell function. Indian J Exp Biol. 2014 Oct;52(10):983-8.
  • Mishra A, Italia K, Gupta M, Desai M, Madkaikar M. Hyperimmunoglobulin syndrome due to CD40 deficiency: possibly the first case from India. J Postgrad Med. 2015 Jan-Mar;61(1):46-8.
  • Madkaikar M, Gupta M, Chavan S et al. X-linked hyper IgM syndrome: clinical, immunological and molecular features in patients from India. Blood Cells Mol Dis. 2014 Sep;53(3):99-104.
  • Mhatre S, Madkaikar M, Desai M, Ghosh K. Spectrum of perforin gene mutations in familial hemophagocytic lymphohistiocytosis (FHL) patients in India. Blood Cells Mol Dis. 2015 Mar;54(3):250-7.
  • Madkaikar M, Italia K, Gupta M, et al.Molecular characterization of leukocyte adhesion deficiency-I in Indian patients: Identification of 9 novel mutations. Blood Cells Mol Dis. 2015 Mar;54(3):217-23.
  • Madkaikar M, Italia K, Gupta M, Desai M, Aggarwal A, Singh S, Suri D, Mishra A, Chavan S, Ghosh K, Sarangal R, Dogra S. Leukocyte Adhesion Deficiency-I with a Novel Intronic Mutation Presenting with Pyoderma Gangrenosum- Like Lesions. J Clin Immunol. 2015 Apr 16.
  • Garg S, Shanmukhaiah C, Marathe S, Mishra P, Babu Rao V, Ghosh K, Madkaikar M. Differential antigen expression and aberrant signaling via PI3/AKT, MAP/ERK, JAK/STAT, and Wnt/β catenin pathways in Lin-/CD38-/CD34+ cells in acute myeloid leukemia. Eur J Haematol. 2015 May 23. doi: 10.1111/ejh.12592.
  • Primary Immunodeficiency Disorders, Heamatological Malignancy, Marrow failure syndrome, Flow Cytometry, Molecular Biology