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Transfusion Medicine

About

This department (earlier known as Red Cell Serology Dept) was started in 1957 with the objectives of solving immunohaematological problems related to blood transfusion, conducting research in the field of transfusion medicine and to train blood bank personnel. Also as unit of this department, Rh antenatal clinic was started (initially at Nowrosjee Wadia Maternity Hospital) to evaluate the role of Rh immunization in context to neonatal jaundice. Many studies have been conducted on HDN (ABO & Rh) like incidence of Rh immunization, foeto maternal leak, anti D quantitation by different methods, influence of tetanus toxoid injection in ABO-HDN etc. The Department was part of the group responsible for creating facilities of intrauterine transfusion at Wadia hospital.

During the course of these activities, rare red cell phenotypes and antibodies have been discovered, detected and identified. The department has to its credit the discovery of rare blood groups like Bombay phenotype (1952) and Ina antigen of Indian blood group system (1973). The current research work in Dept focuses on standardising various DNA based assays to solve complex problems in blood grouping. Department is also involved in the molecular characterization of ABO & Rh D variants and minor blood group antigen profiling. Molecular epidemiology study of weak D allele in the Indian population has led to discovery of a new genetic mechanism producing weak D phenotype in Indians and an Indian-specific genotyping assay has been developed.

A registry of Bombay phenotype individuals has been maintained by department for last five decades and whenever requests come in from any part of India or internationally, donors are contacted and are asked to donate for these patients. We also have a database of regular ‘O’ group blood donors phenotyped for clinically important antigens and antigen negative inventory for giving antigen matched blood to thalassemic patients.

Training of blood bank personnel from different parts of India has been an important activity of the department for last five decades and more than 1000 Medical Officers and Technicians have benefited by this annual training programme. It is an extensive lecture and hands on training program in basic red cell serological techniques for a period of one month.

Department Staff

Sr. No. Name Designation Email ID
1 Dr. Swati Kulkarni Scientist D swatiskulkarni@gmail.com
2 Dr. Naga Muralidhar M Scientist-B biomurali222@gmail.com
3 Ms. Seema Jadhav Sr. Technical Officer (3) seemajadhav66@yahoo.co.in
4 Ms. Monali Gajbhiye Technical Assistant
5 Mr. S. D. Survade Technician C
6 Mr. Tushar Shivtarkar Technician A
7 Mr. Govind Kamraj Lab Assistant
8 Mr. Harishchandra Pawar Lab Assistant

Projects

Dept of Transfusion medicine

  • Identification and molecular characterization of D variants among apparently RhD negative individuals CSIR funded project
  • Establishment of basic red cell serology techniques as a part of pretransfusion investigations in the North East region of India (Project approved by ICMR under Translational research)
  • Human Genetic polymorphisms and Malaria: A study in tribal population in Maharashtra (Funded by Department of Biotechnology)
  • Studies on ‘Bombay’ Phenotype (Intramural)
  • Non invasive prenatal RhD typing (Intramural)
  • Molecular genotyping of Kell, Duffy and Kidd blood group systems (Intramural)
  • Comparative Analysis of Red Blood Cell Antigen typing among the indigenous population of Meghalaya and Native population of Mumbai. (Funded by Department of Biotechnology)
  • Genetic Determinants for Expression of Duffy Antigens on Red Blood Cells and their Interaction with Plasmodium vivax (Intramural)
  • Study on Human neutrophil antigens (HNAs) and associated antibodies (Intramural)
  • Study of Fucosyltransferases (FUT1, FUT2 and FUT3) haplotypes and their association with some autoimmune disorders (Intramural)
  • Molecular study of RH gene variants in Indians (project funded by CEFIPRA) Collaboration with Dr. Yann Fichou, Etablissement Français du Sang Bretagne, Inserm UMR1078, BREST, France
  • Comparative study of red cell antigen profile among Malaria infected patients and normal population from Assam (Extramural ICMR-NE Twinning Project)
  • DNA analysis of blood group antigens (Intramural)
  • Study Of Molecular Mechanisms Underlying RhD Negative Phenotype In Indian Population (Intramural)
  • Serological identification and molecular characterization of RhD variants among apparently RhD negative Individuals from South India (Intramural)
  • Study of MNS blood group system variants in Indians (Intramural)