ICMR-NIIH

आई सी एम आर - राष्ट्रीय प्रतिरक्षा रुधिर विज्ञान संस्थान

ICMR-National Institute of Immunohaematology

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Ongoing Projects
1 A comprehensive longitudinal cohort study for organ damage amoung sickle cell disease patients.
2 Study of Hemoglobinopathies and G6PD Deficiency among Tribals of Tamilnadu.
3 Assessment of neonatal screening approaches for Sickle Cell disease and the effect of early intervention in management of the disease in tribal populations.
4 Training of in-service clinicians from Government Hospitals and outreach programme for aspirational Districts (NANDURBAR) - Screening and Counselling for Genetic Disorders: Incorprorating Prevention of Genetic Disorders in Maternal & Child Health.
5 Screening, Counseling and awareness for the Prevention of sickle cell Haemoglobinopathies in Tea Garden Communities of Upper Assam
6 National Registry for Rare and other Inherited disorders (NRROID).
7 Development of indigenous reagent red cell panels for identificaton and characterization of blood group alloantiboides in North East India.
8 To explore immune players in Hepatitis B viral infection
9 To determine the prevalence of serological and molecular markers of Hepatitis B virus in voluntary blood donors from Maharashtra region (National Health Mission Maharashtra)
10 National External Quality Assessement for HIV Testing (NACO-MDACS Project)
11 Study of Clinical and genetic Predictors of Prognosis in Myelodysplastic Syndromes
12 Incidence of Imatinib resistance and associated BCR-ABL kinase domain mutations among Chronic Myeloid Leukaemia Patients in North East Indian Population
13 Study of Splice Factor mutations and risk assessment in Primary Myelodyspalstic Syndromes.
14 Development of simple novel and rapid diagnostic methods for Glanzmann thrombasthenia
15 Comprehensive genomic and functional evaluation of Factors influencing myocardial infarction in young patients
16 Phenotypic and Genotypic evaluation of Thrombotic Thrombocytopenic Purpura in Indian patients.
17 Longitudinal analysis of Neutralizing and Non neurtralizing antibodies to factor VIII in Hemophilia A patients subclasses, Heterogeneity, Diagnostic and Clinical Implications.
18 Clinical spectrum and molecular basis of Thrombotic Microangiopathies.
19 Screening and Laboratory assessment of PWH Registered with HFI
20 Comprehensive immune profiling and its correlation with response to therapy and underlying genetic variations in Immune Thrombocytopenia (ITP).
21 Study of micro-RNA expression profile in common variable immunodeficiency disorder
22 Clinical, Immunological and Molecular characterization of an Autoimmune Lymphoproliferative Syndrome (ALPS) and B-cell expansion with NF?? and T- cell anergy(BENTA) in Indian population.
23 ICMR Task force study on Rational Use of Medicines
24 Study on Polio and Non-Polio enterovirus infections in children withimmunodeficiency at multiple medical institutes across India. Phase II
25 Defining immunological markers for response to therapy in Aplastic Anemia
26 A non-inferiority randomized trial to assess the efficacy of 10mg hydroxyurea/kg/day versus 20mg hydroxyurea/kg/day in treatment of Sickle cell disease patients of tribal and non-tribal areas in India
27 Exploring lymphocyte subsets and cytokine profile in Pediatric Inflammatory Multisystem Syndrome temporally related to SARS-CoV-2 infection (PIMS-TS). (Intramural)
28 To study the role of mitochondrial DNA damage due to iron overload in transfusion dependent Thalassemia major
29 Identification and molecular characterization of weak D variants among apparently RhD negative individuals from South India (Intramural project in collaboration with JIPMER)
30 Exploring immune players in clinical conditions of HBV infection.
31 Study of genetic factors and immune parameters focusing on the transmission of HBV in household contacts of classical HBV cases
32 Role of endothelial dysfunction and inflammatory process in ineffective erythropoiesis and the clinical severity of hemoglobinopathy patients.
33 Study of molecular pathology of Idiopathic Aplastic Anemia
34 Clinical, Molecular and Cytogenetic Study of Myeloproliferative neoplasms
35 Study of genome wide expression profiling of long non coding RNAs (lncRNAs) and mRNA association with myelodysplastic syndromes pathogenesis
36 Study of the molecular mechanism of bone marrow failure and cancer risk in Fanconi anemia complementation groups
37 The role of epigenetic factors in Fanconi anemia phenotype and cancer predisposition
38 Study of DNA methylation of Polycomb genes and micro RNAs in Drug Resistance CML patients
39 Platelet phenotyping (surface receptors, granules, secretion, and signal transduction) and genotyping of unclassified heritable thrombocytopenia and platelet function disorders.
40 Role of Ion Channelopathies in Sickle Cell Disease
41 To study the role of Regulatory T cells in failure to mount an adequate immune response post-Hepatitis B vaccination
42 Immune response to precautionary third dose of COVISHIELD/COVAXIN among healthy adult population: an ICMR Cohort study, India
43 Centre for Product Development: Tranexamic acid combined with recombinant factor VIII for haemophilia patients- (ICMR)
44 Centre for Product Development: Development of G6PD point of care test (ICMR)
45 Antibody Profile in post- vaccinated individuals when compared to post-COVID-19 patients
46 A flow cytometry assay and rapid agglutination test for the detection of anti-FVIII antibodies- SERB
47 Multi Centric Collaborative Study of the National Registry for Rare Disorders in India- Bleeding disorders
48 Studies on ABO histo?blood group genes and ACE2 as potential genetic susceptibility factors to SARS-CoV-2 infections: an exploratory study
49 CRISPR mediated genetic correction of Sickle Cell disease towards clinical trials in a small patient cohort
50 Study of microRNA expression profile in Common Variable Immunodeficiency disorders (CVID)
51 Strengthening of ICMR-MRUs: Establishment of Autoimmune Diagnostic Laboratories for early detection and management of Autoimmune Disease and empowering MRUs for research in autoimmunity
52 Role of angiotensin converting enzyme 2 and vitamin D in endothelial dysfunction among COVID-19 patients from Mumbai, Maharashtra
53 A study to assess the prevalence of Vitamin B12 deficiency in pregnant women in tribal area.
54 Barriers for Hydroxyurea treatment in sickle cell disease.
55 Glucose-6-Phosphate Dehydrogenase Deficiency among Three Tribes of Assam, India and its significance for Antimalarial Therapy.
56 Radiation Sensitivity Assessment In Inborn Erroras Of Immunity ( IEI ) Patients with Actinopathies
57 Understanding the Genomics of Primary Immune Disorders ( PID) using Next Generation Sequencing (NGS).
58 Immuno-profiling Consortium- Integration of Extended Immune Monitoring (ExImM) and clinical parameters for early prediction of disease trajectory/progression, treatment planning, and prophylaxis to improve COVID-19 prognosis.
59 FPID-NIIH Regional Diagnostic Centre for Primary Immunodeficiency Diseases
60 Center of Excellence for Research, Diagnosis, and Management of Primary Immunodeficiency Disorders (PID).
61 Training of in-service clinicians from Government Hospitals and outreach programme for aspirational Districts - Skill Development in Genetic Diagnosis of Inherited Hematological and Immunological Disorders
62 Molecular studies of Keap1-Nrf2 signalling axis in the pathophysiology of Sickle cell disease: an exploratory study
63 Studies on the role of CD47/SIRP?-interaction in regulation of erythrophagocytosis
64 Congenital Dyserythropoietic Anemias: Molecular Diagnosis and Diagnostic Approach in a Cohort of Indian Patients
65 Prevalence and Molecular Characterization of NADH Cytochrome B5 reductase deficiency in India.
66 Molecular Characterization of unexplained cases of congenital anaemia using next generation sequencing panel.
67 Role of Ion Channelopathies in Sickle Cell Disease
68 Simple APTT Based Tests for Differential Diagnsis of Hemophilia A & B.
69 Centre of Excellence for Advanced Research in Immunohaematology and Transfusion Medicine and create a National Rare Donor Registry.
70 Use of advanced genomics in solving complex serological problems in a Transfusion setting.
71 Identification of molecular signarure ( genetic variants) influencing the phenotypic diversity in beta-hemoglobinopathies by genome wide association studies
72 Risk factors for Covid Associated Mucormycosis in India: A case control investigation.
73 A multicentric study on Systemic Lupus Erythematous (SLE) from the North Eastern Region of India: Early diagnosis to research potential for understanding disease pathogenesis.

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