आई सी एम आर - राष्ट्रीय प्रतिरक्षा रुधिर विज्ञान संस्थान

ICMR-National Institute of Immunohaematology

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Awards & Achievements

  • Simple diagnosis of Glanzmanns thrombasthenia and its carriers. (Applied)
  • Concentration of microfilaria from peripheral blood using a simple technique. (Applied)
  • Development of simple NK Cell assay by flow Cytometry. (Applied)
  • A cell line to study anti viral compounds against some arboviruses for development of antiviral compounds.
  • Developed “Indian-specific PCR genotyping assay” for identification of D variants.
  • A simple POC semi-quantitative test for diagnosis severe von Willebrand disease using gold nanoparticle labelled antibodies (under review with ICMR IPR Dept)
  • RHD gene allele associated with a weak D phenotype and its uses ( Patent filed in Europe on March 8, 2017 under number 17 305246.5.)
  • A Kit For Extended Blood Group Determination And Method Thereof (Patent filed in Jan 2018)
  • A synergistic combination of antimalaial drugs. Patent filed with Patent Office,Govt of India in May 2016 (Patent No.2085/MUM/2015)
  • A Patent has been awarded for “A process for the preparation of diagnostic kit for detection of b-thalassemia syndromes” by Patent Office. Govt. Of India in January 2005 (No.194149). This was submitted by RB Colah, AC Gorakshakar and D. Mohanty in December 2001
Discoveries and Innovations
  • Discovery of “ Bombay ” blood group.
  • Discovery of novel LDH variant in association with HBsAg.
  • Discovery of Indian (Inª) blood group.
  • Detection of rare antigens like M g, I-i-, Ry, Rz alleles, Co(a-b-), homozygous D.
  • Detection of novel and rare hemoglobin variants like Hb D- Agri, HbM- Ratnagiri respectively.
  • Detection of several novel and rare β-thalassemia mutations.
  • First case of vitamin K dependent coagulation factors deficiency from India .
  • Protective effect of EACA (Epsilon Amino Caproic Acid) on factor VIII inhibitor dependent destruction of factor VIII.
  • Detection of novel mutations in Glanzmann’s thrombasthenia.
  • Correlation between chronic synovitis and HLA B 27 in patients with severe hemophilia.
  • Gene mapping of new marker chromosome using FISH.
  • Novel translocation in MDS ( Myelo Dysplastic Syndrome ).
  • Novel HLA alleles in patients with seronegative spondarthritis, hemophilia and leprosy.
  • HLA association with ANCA (Anti Neutrophil Cytoplasmic Antibodies) patients.
  • Identified several novel mutations causing coagulation factor deficiencies (factor IX, factor VII, factor X) and protein C gene.
  • Development of an ELISA assay for factor VIII antibody.
  • Development of ELISA for identification of weaker variants of A and B.
  • Development of ELISAs for C1q, ANA, anti-id, anti-Histone antibodies.
  • Strong association of microparticles of tissue factor and endothelial cell origin with unexplained recurrent pregnancy loss.
  • Microparticles as predictive markers for monitoring anticoagulant therapy in patients with unexplained pregnancy loss.
  • A simple clot based assay for detecting procoagulant microparticles. The in-house test measures the clotting time after the addition of calcium chloride to microparticle rich plasma, following incubation with Russell viper venom and phospholipid free plasma.
  • Microparticles as predictive biomarkers for preeclampsia and IUGR.
  • A specific and sensitive APTT based inhibitor screening assay using purified factor concentrate.
  • Large F8 gene rearrangements and IL10 promoter polymorphisms as strong risk factors for inhibitor development in Indian hemophilia A patients
  • A nationwide survey of hemophilia patients for inhibitors; An overall prevalence of 7.92% with wide regional variation.
  • Mutation profile of hemophilia A, hemophilia, B , VWD, Bernard Soulier syndrome, Glanzmanns thrombasthenia and all the rare coagulation factor deficiencies
  • Dengue virus preferentially infects megakaryocytic colony forming cells. Development of a cell based model for dengue virus infection.
  • A quick mismatched RFLP technique for detecting the founder mutation in mild to moderately deficient hemophilia B cases from Gujarat.
  • Demonstration that clinical severity of haemophilia due to severe disease causing mutation is modulated by co-inherited thrombophilia genes .
  • New clinical classification of severe hemophilia based on thromboelastogrphy.
  • A strong association of HLAB27 with chronic haemophilic synovitis.
  • Unusual association of factor V Leiden with Budd Chiari Syndrome.
  • Human platelet antigen genotype profile in Indian population and its application in neonatal alloimmune thrombocytopenia (NAITP)
  • Development of CRDB kit for detection of common beta thalassemia mutations in India.Participated in "Medical Science and Biotechnology Innovation Exhibition" at Rashtrapati Bhawan , New Delhi on 11th March 2015 and displayed the RDB kit.
  • Rapid Flow cytometric prenatal diagnosis of primary immunodeficiency (PID) disorders
  • A simple clot based assay for detection of procoagulant cell-derived microparticles.
  • Phenotypic Prenatal Diagnosis of Chronic Granulomatous Disease: A Useful Tool in the Absence Of Molecular Diagnosis.
  • Concentration of NADH-cytochrome b5 reductase in erythrocytes of normal and methemoglobinemic individuals measured by Microplate Reader.
  • Warfarin Dose Model for the Prediction of Stable Maintenance Dose in Indian Patients.
  • A specific and sensitive activated partial thromboplastin time (APTT)-based factor VIII inhibitor screening assay

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By Rail : Nearest railway stations to reach NIIH are Dadar/ Prabhadevi station (Western Railway), Parel (Central Railway) and Sewri (Harbour Railway)..

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